The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of cefixime and dicloxacillin sodium in tablet dosage form. In absorbance ratio method, the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Cefixime and dicloxacillin sodium show an isoabsorptive point at 224.7 nm in methanol. The second wavelength used is 289 nm, which is the λ-max of cefixime in methanol. The linearity was obtained in the concentration range of 3-16 μg/ml for both the drugs. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of cefixime. The method was successfully applied for the determination of these two drugs in tablet dosage form. No interference was observed from excipients present in the tablet. The suitability of this method for the quantitative determination of cefixime and dicloxacillin sodium was proved by validation. The proposed method was found to be simple and sensitive for the routine analysis of these two drugs in tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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